Spinal Repair Unit

Using the cell transplantation approach to repair spinal cord and other CNS injuries

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Confocal images (A) Cultured OECs expressing p75 and S100; (B) OECs encapsulated in collagen gel; (C) OECs growing on nanofibres; (D) Repaired dorsal root fibres with transplantation of OECs and (E) Repaired spinal cord fibres by transplantation of OECs.

Scientific Lead:

Clinical Lead:

Research Team:

Research Goals

To develop a repair method for spinal cord and other CNS injuries using transplanted olfactory ensheathing cells derived from the olfactory system.
To establish high-quality cell production, applicable bridging materials and surgical approaches.
To translate successful results in experimental models to patients.

Funded Research Projects

Repair spinal cord injuries by transplantation of olfactory ensheathing cells. Establish consistent quality of cell production, suitable bridging material and surgical approaches.

Funded by the UKSCF and NSIF

Recent publications from Spinal Repair

Kamile Minkelyte, Daqing Li and Ying Li, Ahmed Ibrahim. Transplantation of cryopreserved Olfactory Ensheathing Cells restores loss of functions in an experimental model. Accepted and waiting for publication in Cell Transplantation.

2021

Kamile Minkelyte, Andrew Collins, Modinat Liadi, Ahmed Ibrahim, Daqing Li and Ying Li. High-Yield Mucosal Olfactory Ensheathing Cells Restore Loss of Function in Rat Dorsal Root Injury. Cells, 10, 1186. 2021

2020

Afshari FT, Choi D, Russo A. Controversies regarding mobilisation and rehabilitation following acute spinal cord injury. Br J Neurosurg, online 1st January 2020.

Bartlett RD, Burley S, Phillips JB, Choi D.听 Cell therapies for spinal cord injury:听 trends and challenges of current clinical trials.听Neurosurgery, online 4^th June 2020

Depreitere B, Ricciardi F, Arts M, Balabaud L, Bunger C, Buchowski JM, Chung CK, Coppes MH, Fehlings MG, Kawahara N, Martin-Benlloch JA, Massicotte EM, Mazel C, Meyer B, Oner FC, Peul W, Quraishi N, Tokuhashi Y, Tomita K, Verlaan J-J, Wang M, Crockard HA, Choi D. How good are the outcomes of instrumented debulking operations for symptomatic spinal metastases and how long do they stand? A subgroup analysis in the global spine tumor study group database. Acta Neurochirurgica, online 17th January 2020.

Hill CS, Muirhead WR, Vakharia VN, Marcus HJ, Choi D.听 An exit strategy for resuming nonemergency neurosurgery after severe acute respiratory syndrome Coronavirus 2:听 A United Kingdom perspective.听听World Neurosurgery, online 4^th June 2020

2018

Choi D. Expert鈥檚 comment concerning Ground Rounds case entitled 鈥楳alignant triton tumor: Grand Round presentation of a rare aggressive case thoracolumbar spine tumor鈥� by S Ghailane et al. European Spine Journal, 18 April 2018.

Choi D. Expert鈥檚 comment concerning Grand Rounds case entitled 鈥業diopathic spinal cord herniation: consideration of its pathogenesis based on the histopathology of the dura mater鈥� by S Shimuzu et al. European Spine Journal, 19 April 2018.

Georgiou M, Reis JND, Wood R, Esteban PP, Roberton V, Mason C, Li D, Li Y, Choi D, Wall I. Bioprocessing strategies to enhance the challenging isolation of neuro-regenerative cells from olfactory mucosa. Scientific Reports 2018; 8(1)

Liadi M, Collins A, Li Y, Li D. The impact of tissue storage conditions on rat olfactory ensheathing cell yield and the future clinical implications. Cell Transplantation 2018; 27(9): 1320-1327

2017

Collins A, Li D, Liadi M, Tabakow P, Fortuna W, Raisman G, Li Y. Partial recovery of proprioception in rats with dorsal root injury following human olfactory bulb cell transplantation. Journal of Neurotrauma, online 29 Dec 2017. DOI: 10.1089/neu.2017.5273

Galgano M, Fridley J, Oyelese A, Telfian A, Kosztowski T, Choi D, Gokaslan ZL. Surgical management of spinal metastases. Expert Review of Anticancer Therapy 2018; 18-5:463-472.

Huang H, Young W, Chen L 鈥�. Li Y, Li D 鈥� Li T. Clinical cell therapy guidelines for neurorestoration (IANR/CANR 2017). Cell Transplantation 2018; 27-2; 310-324.

Lui J, Sayal P, Choi D. Spinal cord suspension using dentate ligament hitch stitches: a novel technique for the repair of ventral spinal cord herniation. Operative Neurosurgery 2018; 14-3:252-258.

Lui JYC, Sayal P, Prezerakos G, Russo V, Choi D, Casey ATH. The surgical management of dysphagia secondary to diffuse idiopathic skeletal hyperostosis. Clinical Neurology and Neurosurgery 2018; 167:36-42.

Turner I, Kennedy J, Morris S, Crockard A, Choi D. Surgery and radiotherapy for symptomatic spinal metastases is more cost effective than radiotherapy alone: a cost utility analysis in a UK spinal center. World Neurosurgery, online 1 January 2018.

Wright E, Ricciardi F, Arts M, Buchowski JM, Chung CK, Coppes M, Crockard A, Depreitere B, Fehlings M, Kawahara N 鈥�.Choi D. Metastatic spine tumor epidemiology: comparison of trends in surgery across two decades and three continents. World Neurosurgery, online 20 March 2018.

Turner I, Kennedy J, Morris S, Crockard A, Choi D.听听 World Neurosurgery, online 1 January 2018.听 DOI:听10.1016/j.wneu.2017.09.189

2017

Collins A, Li D, McMahon SB, Raisman G, Li Y. Cell Transplantation 2017; Vol. 26(5):913-924. doi: 10.3727/096368917X695353. Epub 2017 Mar 23.

Nater A, Martin AR, Sahgal A, Choi D, Fehlings MG. PLoS One 2017 Feb 22;12(2):e0171507. doi: 10.1371/journal.pone.0171507. eCollection 2017.

2016

Bartlett RD, Choi D, Phillips JB. . Regenerative Medicine 2016 Oct;11(7):659-73. doi: 10.2217/rme-2016-0065. Epub 2016 Sep 5.

Borg A, Kirkman MA, Choi D. . 2016 Nov;95:383-391.doi: 10.1016/j.wneu.2015.12.105. Epub 2016 Mar 4.

Oprych K, Cotfas D, Choi D. Brain Struct Funct 2017; 222(4):1877-1895. doi: 10.1007/s00429-016-1313-y. Epub 2016 Oct 7.

Verlaan JJ, Choi D, Versteeg A et al. J Clin Oncol. 2016;34(25):3054-61.doi: 10.1200/JCO.2015.65.1497. Epub 2016 Jul 11.

2015

Li Y, Li D, Raisman G. Cell Transplantation 2016; 25 (2): 293-9. doi: 10.3727/096368915X688551. Epub 2015 Jun 30.

2014

Tabakow P, Raisman G, Fortuna W, Czyz M, Huber J, Li D, Szewczyk P, Okurowski S, Miedzybrodzki R, Czapiga B, Salomon B, Halon A, Li Y, Lipiec J, Kulczyk A, Jarmundowicz W. Cell Transplantation 2014; 23 (12), 1631-55. doi: 10.3727/096368914X685131. Epub 2014 Oct 21.

Further information

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皇家华人