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UCL Queen Square Institute of Neurology

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Headache and Facial Pain

headache

Researching headache and facial pain pathophysiology, diagnosis and therapeutics

Lead:

听听

Research Team

  • Dr Linda D鈥橝ntona
  • Dr Andrew Levy

Research Goals

  • To understand the underlying mechanisms of headache and facial pain disorders
  • To understand the genetic basis of headache and facial pain disorder
  • To define the clinical spectrum of headache and facial pain disorders, systematically studying their clinical phenotypes, and thereby improve the classification of these disorders
  • To develop a self-management programme for chronic headache disorders
  • To advance therapeutics by conducting controlled trials in headache and facial pain syndromes
  • To develop and improve innovative surgical and neuromodulatory treatments for headache and facial pain disorders

Funded Research Projects

  • Chronic Headache Education and Self-Management Study (CHESS). Collaborative study with Warwick University. Funded by National Institute of Health Research (NIHR)
  • Cluster Headache Genome Wide Association Study (GWAS). Funded by Brain Research Trust
  • Synaptopathies Study. Funded by Wellcome Trust
  • Occipital Nerve Stimulation in Primary Headache Syndromes. Funded by St Jude Medical
  • Nasal Cavity Cooling for the symptomatic relief of migraine (BrainCool-Migraine) study. Collaborative study with Cumbria Partnership NHS Foundation Trust. Funded by BrainCool AB

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Recent publications from Headache and Facial Pain

2020

Tso AR, Brudfors M, Danno D, Grangeon L, Cheema S, Matharu M, Nachev P
Machine phenotyping of cluster headache and its response to verapamil
Brain, 23 November 2020

Stubberud A, Tronvik E, Matharu M
Treatment of SUNCT/SUNA, Paroxysmal Hemicrania, and Hemicrania Continua: An Update Including Single-Arm Meta-analyses
Current Treatment Options in Neurology 22(12):11 Nov 2020

D'Antona L, Craven CL, Merchan MAJ, Thompson SD, Bremner F, Thorne L, Matharu M, Watkins L, Toma A
Paradoxical response of intracranial pressure to shunt valve setting adjustments
Acta Neurochirurgica: the European journal of neurosurgery 01 Oct 2020 162, pages2451鈥�2458(2020)

Lagrata S, Cheema S, Watkins L, Matharu M
Long-Term Outcomes of Occipital Nerve Stimulation for New Daily Persistent Headache With Migrainous Features
Neuromodulation, 30 Sep 2020

Crespi J,听Bratbak D,听Dodick DW, Matharu M,听Solheim O,听Gulati S,听Berntsen EM,听Tronvik E.听 Open-label, multi-dose, pilot safety study of injection of Onabotulinumtoxin A toward the otic ganglion for the treatment of intractable chronic cluster headache.听 听Headache, online 25th June 2020

D'Antona, Craven CL,听Merchan MAJ,听Thompson SD,听Bremner F,听Thorne L, Matharu M, Watkins L, Toma A.听 Paradoxical response of intracranial pressure to shunt valve setting adjustments.听Acta Neurochirurgica: the European Journal of Neurosurgery, online 11th June 2020

Grangeon L,听O'Connor E,听Chan C-K,听Akijian L,听Pham Ngoc TM, Matharu MS.听 New insights in post-traumatic headache with cluster headache phenotype: a cohort study.听 Journal of Neurology, Neurosurgery & Psychiatry, online 7th May 2020

O'Connor E, Simpson BS, Houlden H, Vandrovcova J, Matharu M.听 Prevalence of familial cluster headache:听 a review and meta-analysis.听 The Journal of Headache and Pain, 21(1); 27

Patel S,听Achana F,听Carnes D,听Eldridge S,听Ellard DR,听Griffiths F,听Haywood K,听Hee SW,听Mistry D,听Mistry H,听Nichols VP,听Petrou S,听Pincus T,听Potter R,听Sandhu HK,听Stewart K,听Taylor S,听Underwood M, Matharu M.听 Usual care and self-management support programme versus usual care and a relaxation programme for people living with chronic headache disorders:听 a randomised controlled trial protocol (CHESS).听 BMJ Open 10(4):e033520 12 Apr 2020
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Stubberud A,听Cheema S,听Tronvik E, Matharu M.听 Nutcracker syndrome mimicking new daily persistent headache: A case report.听 Cephalalgia 333102420918554 15 Apr 2020听

2018

Akram H, Matharu M, Zrinzo L. Optimal deep brain stimulation site and target connectivity for chronic cluster headache-author response. Neurology 2018; 91(4):194.

Davies PTG, Lane RJM, Astbury T, Fontebasso M, Murphy J, Matharu M. The long and winding road: the journey taken by headache sufferers in search of help. Primary Health Care Research and Development 2018 online.

Skljarevski V, Matharu M, Millen BA, Ossipov MH, Kim BK, Yang JY. Efficacy and safety of galcanezumab for the prevention of episodic migraine: results of the EVOLVE-2 Phase 3 randomized controlled clinical trial. Cephalalgia 2018; 38(8): 1442-1454.

Crespi J, Bratbak D, Dodick D, Matharu M, Jamt酶y KA, Aschehoug I, Tronvik E. Measurement and implications of the distance between the sphenopalatine ganglion and nasal mucosa: a neuroimaging study. The Journal of Headache and Pain 2018; 19(1):14.

2017

Matharu MS, Miller S, Lagrata S, Watkins L.听 Headache 2017; 57(10):1610-1613. DOI:听10.1111/head.13187

Akram H, Miller S, Lagrata S, Hariz M, Ashburner J, Behrens T, Matharu M, Zrinzo L.听 听 Neurology 2017; 89(20): 2083-2091.听 DOI:听10.1212/WNL.0000000000004646

Hassan S, Lagrata S, Levy A, Matharu M, Zrinzo L.听 听 Cephalalgia, online 4 October 2017. DOI:10.1177/0333102417735847

Probyn K, Bowers H, Mistry D, Caldwell F, Underwood M, Patel S, et al. BMJ Open. 2017;7(8):e016670. doi: 10.1136/bmjopen-2017-016670.

Matharu M, Pascual J, Nilsson Remahl I, Straube A, Lum A, Davar G, Odom D, Bennett L, Proctor C, Gutierrez L et al. Cephalalgia: an international journal of headache online 31 July 2017 doi: 10.1177/0333102417724150. [Epub ahead of print]

Matharu M, Halker R, Pozo-Rosich P, DeGryse R, Manack Adams A, Aurora SK. The Journal of Headache and Pain 2017; 18(1):78 doi: 10.1186/s10194-017-0784-4. Epub 2017 Aug 1.

Miller S, Watkins L, Matharu M. Cephalalgia: an international journal of headache, online 14 July 2017 doi: 10.1177/0333102417721716. [Epub ahead of print]

Miller S, Matharu M. Current Pain and Headache Reports 2017; 21(3) doi: 10.1007/s11916-017-0608-x.

Miller S, Watkins L, Matharu MS. Journal of Neurology, Neurosurgery and Psychiatry, online 2 March 2017 doi: 10.1136/jnnp-2017-315747. Epub 2017 Mar 2.

Miller S, Watkins L, Matharu M. . European Journal of Neurology, online 1 February 2017 doi: 10.1111/ene.13215. Epub 2016 Dec 20.

Abu Bakar N, Torkamani M, Tanprawate S, Lambru G, Matharu M, Jahanshahi M. (CHQ). 2016 Dec;17(1):79. doi: 10.1186/s10194-016-0674-1. Epub 2016 Sep 5.

2016

Miller S, Akram H, Lagrata S, Hariz M, Zrinzo L, Matharu M. 2016 Oct;139(Pt 10):2631-2640. doi:10.1093/brain/aww204

Miller S, Sinclair AJ, Davies B, Matharu M. 2016 Oct;16(5):362-75. doi: 10.1136/practneurol-2015-001298. Epub 2016 May 5. doi: 10.1136/practneurol-2015-001298. Epub 2016 May 5.

Miller S, Watkins L, Matharu M. . 2016 Dec;17(1):68. doi: 10.1186/s10194-016-0659-0. Epub 2016 Jul 30.

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