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What is uranyl acetate?

Uranyl acetate is a uranium salt, and at »Ê¼Ò»ªÈË is used as a laboratory reagent. It is a yellow, crystalline powder. Uranyl acetate is a radioactive material and UCL is required under the to report all uranium compounds present in the university.

Uranyl acetate is very toxic

Whilst typical laboratory quantities of uranyl acetate do not represent a significant hazard, it is toxic when inhaled or ingested, as uranium is a heavy metal and can damage the kidneys. Ingestion and especially inhalation of uranium compounds can lead to an increased risk of cancer.  

Uranium-free Electron Microscopy stains

A small number of alternative Transmission Electron Microscopy stains have been developed to replace uranyl acetate. These are non-radioactive and non-toxic. They do not require monthly reporting under the Nuclear Safeguards regulations.

A few departments in UCL have tested the alternatives with good results. In general, they are used with the same protocols as you would use for the uranyl acetate staining solution.

Email radreporting@ucl.ac.uk if you are interested and want to find out more.

UCL MarketPlace

The replacement stains usually trade under ‘Uranyl Acetate Replacement’ or ‘Uranyl Acetate Alternative.’ The UranyLess EM Stain brand is available from the UCL MarketPlace (Supplier: Generon), other options are available including UA-Zero and EM Stain 336 (uranyl acetate alternative).

Note: Stains and MarketPlace details were correct at the date of publish.

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