W e are particularly interested in the DC in the skin. In the epidermis, Langerhans cells (LC) form a network that covers the surface of the skin. In the dermis there are at least 2 types of DC, each with specific roles in skin immunity. The high density of different types of DC and the accessibility of the skin make it and attractive site to target DC for immunotherapy. However, DC do not always activate beneficial T cell responses, and they may also cause immunopathology in the skin.