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Editor 鈥� Barbara Kramarz
We have finished Gene Ontology annotation of dementia-relevant microglial gene products
Barbara and Mila have finished Gene Ontology (GO) annotation of the听prioritised听dementia-relevant microglial proteins, resulting in over 1500 annotations contributed for a total of 352 proteins and macromolecular protein complexes, among these over 1000 are for 235 human gene products (Figure 1).听Previously, Rachael, Barbara and Ruth completed annotation of microRNAs that regulate the expression of these microglial proteins and/or are involved in inflammatory processes.听听has also been annotating microRNAs, with a focus on those that regulate expression of the 鈥榞ood鈥櫶齛myloid-betareceptors (reviewed by听, and annotated by us,听), as a听part of her MSc project.Shirin has so far contributed over 100 annotations for around 20 microRNAs bringing the total number of ARUK-UCL microRNA annotations to 1040.听
ARUK-UCL Gene Ontology annotation progress
Overall, since our听ARUK-funded GO annotation听efforts began in January 2017, we have contributed 7528 GO annotations to 1185 distinct gene products, including proteins, microRNAs and macromolecular protein complexes involved in interactions with amyloid-beta and tau as well as in dementia-relevant microglial processes. Of these, 5325 GO annotations have been associated with 711 human gene products (QuickGO accessed: 16thMay 2019). We have also contributed to ontology revisions and development and the number of GO terms, which we have either revised or added to the听ontology since this initiative began has now reached 145 (AmiGO2 accessed: 16thMay 2019).
Gene Ontology annotation of proteins involved in maintenance of the blood-brain barrier
Having completed the听GO annotation of听dementia-relevant microglial proteins and microRNAs regulating their expression, our next focus is the听annotation of proteins implicated maintenance of the听structure of and transport across the听blood-brain barrier(BBB). Following consultations with our Scientific Advisory Panel, including the听Alzforum curators and experts from UCL and University of Manchester, we have selected a听review by听, as the听basis for this project. Mila will annotate the听endothelial connective junctionsin the听brain, described by听, in Figure 2, and Barbara will focus on proteins involved in transport across the听BBB (Figure 3 in the same review). The听priority lists are provided in the听most recent accordion sections on our听ARUK-funded GO annotation听webpage.
Meetings Attended
In March Ruth and Barbara presented posters at the听听in Harrogate and the听Biocuration Conference in Cambridge, where Ruth, Barbara and Mila spent some time catching up with听听of the听UCL team. The听posters听can now be viewed on our website and on F1000.
Two-day Workshop on Bioinformatics Resources and Gene Ontology
In May Ruth and听, a former curator in our team, and currently a听British Heart Foundation PhD student, delivered the 11th听two-day workshop.听This workshop, funded by听, provided an overview of several biological knowledgebases, as well as an introduction to Gene Ontology and functional analysis tools.听We thank听听for their participation and invite their feedback.
Recent Publications
Attrill H, Gaudet P, Huntley RP, Lovering RC, 鈥� Gene Ontology Consortium. Annotation of gene product function from high-throughput studies using the Gene Ontology. Database (Oxford). 2019 Jan 1. doi: 10.1093/database/baz007. PMID:.
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