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UCL Institute of Cardiovascular Science

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Mohammed Shah

PhD Project Title: Investigating the role of extracellular DNA and innate immunity in cell death during ischemia-reperfusion injury in the myocardium.

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Supervisors: Professor Derek Yellon

Lay summary:

Myocardial Infarction (Heart Attack) remains the leading cause of death and cardiovascular morbidity worldwide. Coronary artery occlusion during a Heart Attack results in ischemia; which is a cessation of blood and oxygen to the heart resulting in the death of heart cells. Restoring the blood flow to the myocardium, called reperfusion, after a period of ischemia also results in an intense inflammatory response in the heart which also causes heart cell death, this is called ischemia-reperfusion injury. We aim to gain a better understanding of the inflammation during ischemia-reperfusion injury in the heart and are testing new anti-inflammatory agents in order to protect the heart during a Heart Attack.

My Background 

Prior to embarking on my PhD, I was a Specialist Registrar in Cardiology with extensive experience of working in the NHS as a Clinical Cardiologist throughout Manchester and South London. 
I hope to pursue a dual career as a Research Clinician in the NHS once iv finished my BHF Clinical Research Fellowship here at the Hatter Cardiovascular Institute.

Qualifications

MBChB BSc(hons) MRCP

Awards

BHF Clinical Research Fellowship 2018

Contact details

Mohammed.Shah@ucl.ac.uk