Close
Collaborative publication in Cancer Discovery for de Bruin Lab
The de Bruin lab contributed to a new study from the, at the , published in , investigating the role of APOBEC in cancer evolution. The work shows that APOBEC3 exacerbates DNA replication stress & chromosomal instability in early breast & lung cancer. These findings suggest that APOBEC3 is functionally implicated in the onset of chromosomal instability and somatic mutational heterogeneity in pre-invasive disease, providing fuel for selection early in cancer evolution.
