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New publication in Nature Communications for de Bruin lab
In order for a cell to proliferate聽with 铿乨elity, it must cycle through two non-overlapping events - replication聽of the genomic DNA during S phase and the segregation of the duplicated DNA聽into two聽genetically聽identical daughter cells during M phase.聽DNA聽replication is tightly regulated during S-phase.聽S-phase length is determined by聽DNA synthesis rate, but what controls or聽limits the DNA replication rate remained largely unknown.聽Work published by the de Bruin lab in聽the latest issue of Nature聽Communications shows that cell cycle regulated聽transcription, dependent on E2F transcription factors, determines the DNA聽replication rate and thereby S phase length. E2F-dependent transcription regulates the DNA replication capacity of聽a cell,聽which represents the actual amount of DNA synthesised at a given time during聽S-phase, thereby聽controlling the聽time it takes聽to duplicate the genome.聽Overall their work suggests that the tight regulation of E2F聽transcription in S phase is an important聽determinant in DNA replication control聽and genomic stability, which has important implications for basic biology and聽the聽understanding of cancer.
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