皇家华人

Research article and cover in Dev Cell for Lloyd lab and colleagues

In a recent article in Developmental Cell, the听Lloyd lab and colleagues听characterize the conserved multicellular structures and processes that define the mammalian blood-nerve barrier (BNB). Macrophages enforce the BNB during homeostasis, whereas, following injury, Schwann cells transiently 鈥渙pen鈥� the barrier by increasing transcytosis rates across blood vessels, permitting increased delivery of therapeutics to peripheral nerves.

Cover caption |听Peripheral nerves are protected by the blood nerve barrier. While this provides a protective environment to nerves, it presents a barrier to therapeutic delivery. This image shows endoneurial blood vessels (red, CD31), which all have barrier-function-expressing claudin5 (green), surrounded by other cells that contribute to the barrier, where only nuclei can be seen (white). Image credit: Giulia Casal (image made on ).

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